Time: Early 21st Century -- Place: Italy
Starring Giorno Giovanna, aka "GioGio", the son of Dio, who is working his way up through the ranks of Italian gangsters. Despite who his father is, Giorno is basically a nice guy, and doesn't really have to answer to his father's evil past (of course, due to Dio's strange method of living 100 years, he's got Jonathan Joestar's blood in his veins too, so he is partially a member of the Joestar family. Dio + Jojo = GioGio). This series is more crime-oriented than horror-oriented and is basically a battle of "good Stand Users vs. bad Stand Users" between extremely weird-looking and overdressed Italian mafia hitmen. It's a big break with the past as there are hardly any continuing characters from any of the earlier series.